منابع مشابه
Rab35 drives exosome secretion
Rab35 drives exosome secretion T he GTPase Rab35 regulates the release of small vesi-cles called exosomes from the surface of glial cells, say Hsu et al. Exosomes are formed in the lumen of specialized endosomes called multivesicular bodies (MVBs), which fuse with the plasma membrane to secrete the vesicles extracellularly. The process was fi rst described as a way for differentiating reticuloc...
متن کاملRegulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
Oligodendrocytes secrete vesicles into the extracellular space, where they might play a role in neuron-glia communication. These exosomes are small vesicles with a diameter of 50-100 nm that are formed within multivesicular bodies and are released after fusion with the plasma membrane. The intracellular pathways that generate exosomes are poorly defined. Because Rab family guanosine triphosphat...
متن کاملCortactin enhances exosome secretion without altering cargo
The role of cortactin, a regulator of late endosomal trafficking, in the biogenesis and secretion of exosomes is poorly understood. In this issue, Sinha et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601025) elucidate the role of cortactin as a positive regulator of late endosomal docking and exosome secretion.
متن کاملCortactin promotes exosome secretion by controlling branched actin dynamics
Exosomes are extracellular vesicles that influence cellular behavior and enhance cancer aggressiveness by carrying bioactive molecules. The mechanisms that regulate exosome secretion are poorly understood. Here, we show that the actin cytoskeletal regulatory protein cortactin promotes exosome secretion. Knockdown or overexpression of cortactin in cancer cells leads to a respective decrease or i...
متن کاملQuantitative Analysis of Exosome Secretion Rates of Single Cells.
To study the inhomogeneity within a cell population including exosomes properties such as exosome secretion rate of cells and surface markers carried by exosomes, we need to quantify and characterize those exosomes secreted by each individual cell. Here we develop a method to collect and analyze exosomes secreted by an array of single cells using antibody-modified glass slides that are position...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2010
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1892iti1